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D-dimer analysis is critical for the diagnosis of deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. Modern assays for D-dimer are monoclonal antibody based. The enzyme-linked immunosorbent assay (ELISA) is the reference method for D-dimer analysis in the central clinical laboratory, but is time …

Elevated D-dimer plasma concentrations are common in hospitalized COVID-19 patients and are often associated with a worse prognosis, but it is not yet clear whether this also applies to outpatient cases. The present cross-sectional study evaluated D-dimer levels and their association with clinical parameters and inflammation biomarkers after a ...

A dimer may induce strong biological activity such as the silybin A dimer 60aa, which was more active than the parent molecule 60a on all cells tested, with the exception of skin cells (NAK) . In addition, the testosterone dimer 6a tested on three prostate cancer cell lines displayed activity 12 to 70 times stronger than that of the …

The D-dimer cutoff value for acute or subacute DVT on POD 3 could be set to 3.3 μg/mL; however, the setting resulted in several false-negative cases. Practically, 1.5 μg/mL of the D-dimer cutoff value on POD 3 might be appropriate to avoid false-negative results. Keywords: brain tumor surgery, glioma, deep vein thrombosis, D-dimer ...

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D-Dimer was determined by immunoturbidimetry method in our central laboratory and < 0.8 mg/L was defined as normal. Troponin T and NT-proBNP were determined by Roche assays. Troponin T and NT-proBNP were determined upon admission and then every morning in CCU until they began to reduce from peak value. …

Background: D-dimer values in patients with SARS-2 COVID-19 infection are known to be elevated and have been shown to be a predictor for disease severity, …

The D-dimer measurement is used as a global marker of activation of the coagulation and fibrinolytic systems, and functions as an indirect marker of thrombotic and subsequent thrombolytic activity 1 that influences the accuracy of diagnosis of thromboembolism. D-dimer molecules are generated through the degradation of cross …

The use of D-dimer testing resulted in a significant reduction in the use of ultrasonography, from a mean of 1.34 tests per patient in the control group to 0.78 in the D-d (P=0.008).

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The D-dimer is a by-product of the blood clotting and break-down process that can be measured via analysis of a blood sample. D-dimer is released when a blood clot begins to break down. [1] [2] [3] More specifically, platelets in the blood are connected to a D subunit. When blood clots form, the D group between two platelets form a bond.

In a retrospective study, Schutte et al 14 found that plasma D-dimer levels >5000 μg/L carried a very high predictive value for serious disease. Of their 581 study patients, 93% were diagnosed with VTE, cancer, or infection. VTE (40%) was the most common diagnosis, followed by cancer (29%) and infection or sepsis (24%).

Introduction. Plasma d-dimer, a fibrin degradation product, is a valuable clinical test for detecting acute venous thrombosis.Because it is a broad thrombosis marker, the basal d-dimer concentration also serves as an epidemiological indicator of future cardiovascular disease risk, including coronary heart disease (CHD) and venous …

D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, …

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IntroductionVariable D-dimer trends during hospitalization reportedly result in distinct in-hospital mortality. In this multinational case series from the first and second waves, we show the universality of such …

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Our diagnostic strategy resulted in the use of chest imaging in 34.3% of patients, whereas a strategy in which pulmonary embolism is considered to be ruled out with a low C-PTP and a d -dimer ...

D-dimer is one of the protein fragments produced when a blood clot gets dissolved in the body. It is normally undetectable or detectable at a very low level unless the body is forming and breaking down blood clots. Then, its level in the blood can significantly rise. This test detects D-dimer in the blood.

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D-dimer is resistant to ex vivo activation, relatively stable, and has a long half-life, becoming an appropriate biomarker for acute ischemic stroke. 9 D-dimer was previously identified as marker of poor prognosis, 10–12 stroke severity, 13 stroke subtypes, 7,14 cardioembolic origin, 10,15 or cancer-related stroke. 16,17 The relation …

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D‐dimer, which is a fibrin degradation product, is a biomarker for coagulation and reflects increased thrombosis. 6, 7 Although D‐dimer level has been clearly confirmed to be associated with death in the general population in the long term, 8, 9 only a few studies assessed the association of D‐dimer with death 10, 11, 12 or poor ...

Dealing with D-dimer debacles. An intern in the emergency department has been nervously standing behind you for the past ten minutes while you've dealt with a barrage of phone calls. He wants to discuss the positive D-dimer result of the patient he is working up. You look to the patient's cubicle and see a 30 year-old man looking around ...

D-dimer, a degradation product of cross-linked fibrin, is a marker of hypercoagulability and thrombosis. 1 Moderately high levels of D-dimer have been associated with a risk of subsequent thrombotic events 2 – 11 (venous 12,13 and arterial 6,8,9,11), particularly in patients with prior vascular disease, 14 – 17 and have also been linked to ...

Elevated D-dimer levels during anticoagulant therapy with vitamin K antagonists (VKA) are associated with an increased risk of thrombosis. It has been hypothesized that elevated D-dimer levels in patients receiving direct oral anticoagulants (DOACs) also indicate an increased risk of thrombosis recurrence, but data on the …

D‐dimer is a sensitive but not specific biomarker of venous thromboembolism. D‐dimer has been widely used in new indications since the beginning of the coronavirus disease 2019 pandemic. D‐dimer testing prescription should be strictly limited to approved applications. The coagulation process results in an insoluble clot of …