Question: Questions 13-16: The article "Chronic Beryllium Disease and Sensitization at Beryllium Processing Facility" (K. Rosenman, V. Hertzberg, et al., Environmental Health Perspectives, 2005:1366-1372) discusses the effects of exposure to beryllium in a cohort of workers. Four hundred ninety two workers were categorized by their duration of …

Chronic beryllium disease causes progressive dyspnea, cough, and fatigue. Diagnosis is by history, beryllium lymphocyte proliferation test, and biopsy. Treatment is with …

Beryllium metal, first discovered in France in 1798, has proved to be of great value to the aerospace, nuclear, electronics, and computer industries. Its light weight, stability, considerable hardness, lack of magnetic qualities, and electrical and thermal conductivity properties make beryllium an ideal substance for various "high technology" …

@article{osti_530617, title = {Chronic beryllium disease: Diagnosis and management}, author = {Rossman, M D}, abstractNote = {Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin …

Chronic beryllium disease is an occupational lung disease that begins as a cell-mediated immune response to beryllium. Although respiratory and engineering controls have significantly decreased occupational beryllium exposures over the last decade, the rate of beryllium sensitization has not declined. We hypothesized that skin exposure to ...

Sarcoidosis is a multiorgan disease of unknown cause characterized by nonnecrotizing granulomatous inflammation, most commonly involving the lung.1 Confirming the diagnosis entails ruling out alternative conditions mimicking sarcoidosis.2 Important among these is sensitization to beryllium causing chronic beryllium disease (CBD). …

Symptoms. Diagnosis. Prognosis. Prevention. Treatment. Beryllium disease is a lung inflammation caused by inhaling dust or fumes that contain beryllium. Most people with …

Beryllium disease: the relation of pulmonary pathology to the clinical course and prognosis based on a study of 130 cases from the U.S. Beryllium case registry. Hum Pathol. 1970;1:25–44. Article PubMed CAS Google Scholar Kriebel D, Brain JD, Sprince NL, Kazemi H. The pulmonary toxicity of beryllium.

Chronic beryllium disease (CBD) is a lung disorder related to beryllium exposure and is characterized by the accumulation in the lung of beryllium-specific CD4 + major histocompatibility complex (MHC) class II-restricted T lymphocytes. Evaluation of MHC class II genes in 33 CBD cases and 44 controls has shown a negative association …

Since the initial Occupational Safety and Health Administration (OSHA) ruling on a permissible exposure limit (PEL) for beryllium in 1971, our understanding of the …

Beryllium disease: the relation of pulmonary pathology to clinical course and prognosis based on a study of 130 cases from the U.S. Beryllium …

Chronic beryllium disease; Chronic pulmonary berylliosis; URL of Article. Chronic beryllium lung disease (CBD) or sometimes just simply known as berylliosis refers to lung changes that can be seen with prolonged exposure to beryllium which is an alkaline earth metal that is used in many different industrial applications.

Pathophysiology of Beryllium Disease. Acute beryllium disease is a chemical pneumonitis causing diffuse parenchymal inflammatory infiltrates and nonspecific intra-alveolar edema. Other tissues (eg, skin, conjunctivae) may be affected. Acute beryllium disease is now rare because most industries have reduced exposure levels, but cases were common ...

The association between beryllium and lung disease has been well established. In 1943, Van Ordstrand et al1 reported cases of acute, severe pneumonitis among beryllium processing workers in Lorain, OH. Meanwhile in Massachusetts, Hardy and Tabershaw2 identified a cluster of granulomatous lung disease among fluorescent lighting workers. …

Pulmonary sarcoidosis and chronic beryllium disease (CBD) are inflammatory granulomatous lung diseases defined by the presence of non-caseating granulomas in the lung. CBD results from beryllium exposure in the workplace, while the cause of sarcoidosis remains unknown. CBD and sarcoidosis are both immune-mediated …

Objectives Beryllium sensitisation (BeS) and chronic beryllium disease (CBD) are caused by exposure to beryllium with susceptibility affected by at least one well-studied genetic host factor, a glutamic acid residue at position 69 (E69) of the HLA-DPβ chain (DPβE69). However, the nature of the relationship between exposure and carriage of the DPβE69 …

Introduction. Berylliosis, also known as chronic beryllium disease (CBD), is a granulomatous disease caused by exposure to …

In acute beryllium disease, the metal acts as a direct chemical irritant, causing a nonspecific inflammatory reaction (acute chemical pneumonitis). Due to improved industrial hygiene measures, acute beryllium disease virtually has disappeared and is not discussed in this article.

Chronic beryllium disease (CBD), or berylliosis, is a granulomatous lung disease that results from beryllium exposure and …

Beryllium is a known carcinogenic metal with application in several industries like electronics and high-tech ceramics. It is a granulomatous disease that affects 2-5% of workers exposed to ...

Abstract. The increasing use of beryllium in a variety of industries continues to be a hazard. New cases are still being reported to the UK Beryllium Case Registry, now numbering 60 in the period 1945-1988. The majority of cases follow inhalation which results in acute beryllium disease (chemical pneumonitis) or more commonly chronic beryllium ...

Acute and chronic beryllium disease are caused by inhalation of dust or fumes from beryllium compounds and products. Acute beryllium disease is now rare; chronic …

Acute beryllium disease is a chemical pneumonitis causing diffuse parenchymal inflammatory infiltrates and nonspecific intra-alveolar edema. Acute beryllium disease is now rare because most industries have reduced exposure levels. Chronic beryllium disease continues to occur in industries that use beryllium and beryllium alloy.

This article discusses exposure-response relationships for lung cancer and chronic beryllium disease. We assigned a distribution to cancer slope factor values based on the relative risk estimates from an occupational epidemiologic study used by the U.S. Environmental Protection Agency (EPA) to determine the slope factors.

Occupational lung diseases include a wide spectrum of respiratory disorders with symptoms, signs, and diagnostic test results that often present with features similar to nonoccupational diseases (Table 93-1).For example, adult-onset asthma (Chapter 87) may be occupational asthma, presumed sarcoidosis (Chapter 95) may actually be chronic …

Toxic pulmonary disease from beryllium exposure first came to light in the 1930s, soon after the emergence of industrial uses of beryllium alloys. An early manufacturing application for beryllium compounds, as phosphors in fluorescent tubes, was the cause of some of the first known cases of chronic beryllium disease (CBD) (first termed …

Chronic Beryllium Disease Prevention Program; Final Rule VerDate 29-OCT-99 10:58 Dec 07, 1999 Jkt 190000 PO 00000 Frm 00001 Fmt 4717 Sfmt 4717 E:FRFMA08DE0.189 pfrm04 PsN: 08DER3. 68854 Federal Register/Vol. 64, No. 235/Wednesday, December 8, 1999/Rules and Regulations

Abstract. Metal-induced hypersensitivity is driven by T-cell sensitization to metal ions. Although numerous metals are associated with the development of diffuse …

Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Even though one of largest cohorts …